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Nature
UCHL3 stabilizes ENO1 through deubiquitination to promote glycolysis and tumor growth in bladder cancer

Bladder cancer (BCa) is one of the most common malignant tumors of the urinary system and represents an increasingly serious public health problem worldwide. Dysregulated glycolysis is a key feature of metabolic reprogramming in BCa, and aberrant expression of enolase 1 (ENO1) is closely associated with tumor progression. This study aimed to identify novel deubiquitinases that regulate ENO1 ubiquitination and stability in BCa.

News-Medical
Exercise benefits mental health, so why is the genetic evidence so mixed?

A systematic review of 61 Mendelian randomization studies found limited and inconsistent genetic evidence that general physical activity causally improves mental health or cognitive outcomes; 30 studies reported only null or directionally opposite findings. More consistent evidence emerged for aerobic exercise and reduced depression risk, and for physical fitness traits, particularly muscle strength and muscle mass, in relation to better mental and cognitive health, although methodological limitations prevent definitive causal conclusions.

Phys.org
New study maps the genetic landscape of bovine TB across Wales

Bovine tuberculosis is evolving in different ways across different regions in Wales, according to the most detailed analysis of the bacterium conducted to date. One of the most significant animal health challenges facing Wales, bovine TB affects cattle health and farm businesses and places considerable emotional, social and financial pressures on farming communities.

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